|
KMID : 0861020030180020135
|
|
Korea Journal of Herbology
2003 Volume.18 No. 2 p.135 ~ p.140
|
|
|
Effect of Aconiti Radix on Cultured Rat Myocardial Cells Damaged by Hydrogen Peroxide
|
|
|
|
|
Abstract
|
|
|
Objectives : To examine the cytotoxicity and the effect of Aconiti Radix(AR) on oxygen free radicals in cultured myocardial cells of neonatal rat.
Methods : Toxic effect was measured by MTT assay after myocardial cells were incubated for 4 hours in the media containing 10-40 PM concentrations of H202. In addition, the protective effect of AR was determined in these cultures.
Results : Cell viability was positively decreased in a dose-dependent manner after exposure of 30 μM H₂O₂to cultured rat myocardial cells for 4 hours. In the protective effect, AR prevented the H₂O₂-induced cytotoxicity in these cultures.
Conclusion : From these results, it suggests that H₂O₂has cytotoxicity in cultured rat myocardial cells and AR blocked the cytotoxicity induced by H₂O₂.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|